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有机血管血管化:策略和应用

Qianmin Gao^1,2,3, Jian Wang^1,2,3,4, Hao Zhang⁴

¹Institute of Translational Medicine, Shanghai University, Shanghai, 200444, P. R. China.

Advanced healthcare materials

|April 26, 2025

概括

血管化有机体对于营养递送至关重要,在临床转化中面临挑战. 本综述探讨了用于生物医学研究和治疗应用的有机体中开发功能性血管网络的策略.

科学领域:

生物医学工程生物医学工程
组织工程是组织工程.
再生医学是一种再生医学.

背景情况:

器官体是生物医学研究中至关重要的3D组织模型.
有机体中的血管网络对于营养/氧气供应和废物清除至关重要,支持生长和成熟.
功能性血管化是有机体活力和临床转换的关键,但目前的局限性阻碍了进展.

研究的目的:

审查血管化的有机体的发展.
检查有机体血管化中血管生成和血管生成的机制.
分析构建策略,应用和新兴的器官血管化技术.

主要方法:

审查有关有机血管化的现有文献.
将血管化方法分类为体内和体外方法.
讨论新兴技术,如生物打印和基因编辑.

主要成果:

血管化的有机体为组织相互作用提供了洞察力,并促进了再生.
当前血管化技术的局限性阻碍了有机体的生长,活力和临床转化.
在体内和体外的方法对有机体血管化有明显的优势和局限性.

结论:

在有机血管化方面的进步对模拟疾病和开发疗法充满希望.
生物打印和基因编辑是增强血管化和功能整合的新兴技术.
改善血管化对于推进基于器官的翻译研究和疗法至关重要.

关键词:

血管新生是因为血管新生.有机生物有机物再生医学是一种再生医学.血管化的血管化.血管生成是指血管的产生.

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