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来自Physalis peruviana的生物活性维他诺化物

Mayuramas Sang-Ngern1,2, Ashley Fukuchi1, Tamara P Kondratyuk1

  • 1Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI, United States.

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概括

秘鲁植物 (Poha) 产生的新型化合物是physaperuvin K和physalolactone,具有显著的抗炎性质. 这些化合物抑制关键的炎症通路,显示出药用应用的潜力.

关键词:
新型和化维他诺化物.秘鲁的自然植物.这是一种抗炎药物.开普岛的子果果黄金果 (Goldenberry) 是一个波哈波哈 (poha poha) 是一个词.

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科学领域:

  • 植物化学 植物化学
  • 药理学 药理学是指药理学的学科.
  • 自然产品 化学 化学

背景情况:

  • 秘鲁植物植物 (Physalis peruviana L. Poha) 在传统医学中有着悠久的历史,特别是用于治疗癌症.
  • 了解Poha的化学成分对于验证其药用应用至关重要.

研究的目的:

  • 为了研究Physalis peruviana的化学成分.
  • 评估从Poha.中分离出来的化合物的抗炎潜力.

主要方法:

  • 从新鲜水果和Poha的空气部分中提取和分离化合物.
  • 使用NMR光谱和X射线衍射阐明结构.
  • 在体外测试以评估抗炎活性,包括NF-κB抑制和减少氧化生产.

主要成果:

  • 从果实中分离出一种新型的withanolide,physaperuvin K (1),以及从空气部位中分离出的其他七种withanolides (2-8).
  • 化合物1,2和3显示显著抑制瘤亡因子α诱导的NF-κB活性.
  • 化合物1-3有效地降低了活化巨细胞中氧化的产生,而无细胞毒性.

结论:

  • 这项研究阐明了Physalis peruviana的化学特征,识别了生物活性维他诺化物.
  • 从食用水果中分离出来的Physaperuvin K具有强大的抗炎活性.
  • 这些发现支持Poha的传统药用,并突出了其潜在的治疗价值.