超声波评分系统用于SOS/VOD在儿科造血干细胞移植接受者的SOS/VOD
Mutsumi Nishida1, Shinsuke Hirabayashi2, Takahito Iwai3,4
1Management Strategy Department, Hokkaido University Hospital, N14 W5, Kita-ku, Sapporo, 060-8648, Japan. mutuni@med.hokudai.ac.jp.
International journal of hematology
|April 26, 2025
概括
基于北海道超声波 (美国) 的评分系统 (HokUS-10和HokUS-6) 能够有效地诊断儿科鼻腔阻塞综合征 (SOS) /静脉封闭性疾病 (VOD). HokUS-6为早期pSOS/VOD检测提供了一个实用的替代方案.
科学领域:
- 儿科血液学 儿科血液学
- 移植医学 移植医学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 阴道阻塞综合征 (SOS) /静脉封闭性疾病 (VOD) 是血造细胞干细胞移植后的一种严重并发症,在儿童中更为频繁.
- 现有的诊断工具,如基于北海道超声波 (美国) 的评分系统 (HokUS-10和HokUS-6) 已被验证用于成年人,但其儿科实用性尚不清楚.
研究的目的:
- 评估儿童SOS/VOD (pSOS/VOD) 的HokUS-10和HokUS-6评分系统的诊断准确性.
- 评估这些评分系统在接受血造干细胞移植的儿科患者中的临床适用性.
主要方法:
- 对99名儿科患者的回顾性分析,包括13名被诊断患有psos/vod.
- 基于超声波发现的HokUS-10和HokUS-6评分系统的应用.
- 评分系统结果与psos/vod的临床诊断的相关性.
主要成果:
- 超大胆血是不常见的,但输血耐药性血栓性缺血症,肝壮症和炎是psos/vod患者的一致指标.
- 霍库斯-10的曲线下面积 (AUC) 为0.977 (灵敏度为100%,特异性为80%).
- HokUS-6的AUC为0.957 (灵敏度为77%,特异性为97%),显示出强大的诊断性能.
结论:
- HokUS-10和HokUS-6评分系统是诊断儿科SOS/VOD的宝贵工具.
- 简化的HokUS-6系统是一个实用和有效的替代方案,用于pSOS/VOD诊断,当HokUS-10是不可行的.
- 使用这些基于美国的评分系统,早期发现PSOS/VOD对于及时的临床管理至关重要.
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