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沙吉塔骨脊平衡的变化与多发性骨髓瘤患者的疼痛增加和功能受损有关

Julian Kylies¹, Michael Dirks², Elias Brauneck³

¹Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Hamburg, Germany. j.kylies@uke.de.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

|April 26, 2025

概括

在多发性骨髓瘤 (MM) 患者中,渐进的胸部形 (TK) 和脊柱对齐减少会加剧疼痛,增加止痛需求. 建议对显著的TK增加进行手术纠正,以改善疼痛管理.

科学领域:

在瘤学瘤学.
整形外科整形外科整形外科
放射学放射学是一门学科.

背景情况:

多发性骨髓瘤 (MM) 通常会导致骨解性脊髓损伤.
这些病变会增加骨折风险,并损害脊骨皮层的对齐.
在复发的MM中,脊柱变化加剧了疼痛和功能障碍.

研究的目的:

研究MM患者脊椎骨盆参数变化与临床结果之间的关系.
确定导致疼痛和止痛药的关键脊柱变化.

主要方法:

追溯分析86名MM患者的≥3次全身CT扫描.
在37.5个月的平均随访期内评估脊骨皮层参数和临床数据 (疼痛,止痛药使用,ECOG,ASIA).

主要成果:

观察到胸部位 (TK) 的显著增加和Dens轴-S1距离的减少.
这些变化与疼痛强度 (VAS) 和止痛药使用 (WHO水平) 的增加相关.
一个TK增加>9°强烈与更高的疼痛水平相关;骨折没有显著影响疼痛.

结论:

渐进的TK和减少的Dens轴-S1距离是MM相关疼痛的关键因素.
专注于形纠正的手术策略,特别是TK增加>9°的手术策略,对于疼痛管理至关重要.

关键词:

基索斯 (Kyphosis) 是一种神经的形成.这是一种Lordosis病.多发性骨髓瘤是一种多发性骨髓瘤.疼痛疼痛疼痛疼痛脊柱骨折脊柱骨折脊柱骨折脊柱骨折脊柱骨折脊柱骨折

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