在河南省小麦中使用生理基提取方法评估Mn,Cu,Fe和Cd的生物可访问性
Li Ma1, Xuejin Zhao1, Guobing Lin2
1College of Forestry, Henan Agricultural University, No. 218 Ping An Avenue, Zhengzhou, 450002, Zhengdong New District, China.
Environmental monitoring and assessment
|April 26, 2025
概括
小麦的必需矿物质和有毒的生物可用性因消化阶段而异. 了解这些矿物和金属的生物可访问性水平是准确评估小麦消费对人类健康的风险的关键,特别是对儿童.
科学领域:
- 农业科学 农业科学
- 环境化学环境化学
- 人类营养人类营养
背景情况:
- 在中国,小麦是主食,提供了必需的微量营养素,但由于潜在的有毒元素积累,也带来了风险.
- 了解小麦中金属的生物可访问性对于评估饮食健康风险至关重要.
研究的目的:
- 评估中国河南省小麦粒中 (Mn),铜 (Cu),铁 (Fe) 和 (Cd) 的体外生物可访问性.
- 评估通过小麦消费接触所带来的人类健康风险,考虑到与年龄相关的脆弱性.
主要方法:
- 系统收集河南省54个县的小麦谷物样本.
- 在体外生理提取实验中模拟胃和肠道消化阶段.
- 相关性分析以确定总金属度,生物可访问性和金属之间的相互作用之间的关系.
- 蒙特卡洛模拟评估暴露的健康风险,区分成人和儿童群体.
主要成果:
- (Cd) 的生物可用性从胃到肠的阶段显著下降.
- (Mn) 的生物可用性跟随Cd的类似趋势,而铜 (Cu) 和铁 (Fe) 在肠道阶段显示出更高的生物可用性.
- 较高的总金属度与增加的生物可访问分数相关;Cd生物可访问性与Mn水平有积极的联系.
- 与成年人相比,儿童因小麦传播的Cd暴露面临更高的健康风险,生物可访问性调整显著降低了这些风险.
结论:
- 在小麦中,必需矿物质和有毒元素的生物可访问性在胃和肠道消化阶段之间有很大差异.
- 生物可访问性在调节与食用污染小麦相关的健康风险方面发挥着至关重要的作用,特别是在儿童等弱势群体中.
- 确定元素的生物可访问性和生物毒性之间的准确关系对于开发可靠的人类健康风险评估方法至关重要.
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