呼吸道过敏疾病中的血管内皮生长因子:病理生理功能和治疗前景
Yu Zhang1,2,3,4, Jingyun Li1,2,3,4, Luo Zhang1,2,3,4
1Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Expert review of clinical immunology
|April 26, 2025
概括
血管内皮生长因子 (VEGFs) 是呼吸道过敏疾病的关键,如喘和鼻炎. 准VEGF及其受体为这些疾病提供了有前途的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 过敏学 过敏学
背景情况:
- 血管内皮生长因子 (VEGFs) 对生理血管生成和恒温至关重要.
- 维基基基因在血管恒温和呼吸道过敏疾病 (包括喘和过敏性鼻炎 (AR)) 的病理过程中起着复杂的作用.
- 呼吸道过敏性疾病的流行率不断增加,给经济带来了巨大的负担.
研究的目的:
- 审查关于VEGFs在呼吸道过敏疾病的炎症进展和组织重塑中的研究.
- 总结涉及VEGFs的相关分子通路.
- 探索VEGF及其受体作为过敏呼吸道疾病的潜在治疗点.
主要方法:
- 在PubMed和Web of Science数据库中进行了广泛的文献搜索.
- 审查1989年至2024年间发表的文章.
- 综合关于VEGF参与过敏呼吸道疾病的发现.
主要成果:
- VEGFs与气道过敏疾病的炎症进展和结构重塑有关.
- 已经确定了涉及VEGF及其受体在过敏反应中的特定途径.
- VEGF及其受体已经证明了治疗潜力,与其在瘤学中的使用相似.
结论:
- 了解VEGFs在过敏呼吸道疾病中的复杂作用对于开发向疗法至关重要.
- 在过敏性喘和AR中,VEGF及其受体是新型治疗干预措施的有希望的目标.
- 对VEGF机制的进一步研究可以导致对日益增长的过敏性疾病负担的更有效的治疗方法.
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