来自热带美洲植物的生物活性分子:细胞因子风暴管理的潜在抗炎剂
Erika Plazas1, Lucellys Sierra-Marquez1, Jesus Olivero-Verbel1
1Environmental and Computational Chemistry Group, School of Pharmaceutical Sciences, University of Cartagena, Cartagena 130014, Colombia.
来自热带美国植物的天然化合物可以帮助调节细胞因子风暴. 这些植物性分子显示出降低有害炎症和开发炎症条件的新疗法的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 民族植物学 民族植物学
背景情况:
- 细胞因子风暴,标志着过度的促炎媒介 (TNFα,INFγ,IL-1β,IL-6,GM-CSF),严重恶化急性炎症状况.
- 调节这些高炎症通路对于减少系统性损伤和改善患者的治疗结果至关重要.
研究的目的:
- 探索来自热带美洲植物的生物活性化合物的潜力,调节免疫-炎症通路.
- 确定特定的自然产品及其抵消细胞因子风暴的机制.
主要方法:
- 关于热带美洲植物及其生物活性化合物的科学文献的综述.
- 对关键植物化学物质如多,类和类的免疫调节作用的分析.
- 检查包括NF-κB下调,细胞因子抑制,氧化抑制和炎症酶调节在内的机制.
主要成果:
- 来自诸如 *Achyrocline satureioides* 和 *Mangifera indica* 等植物的多 (奎尔,黄) 降低了NF-κB的调节,并抑制了促炎性细胞因子.
- 来自*Berberis*物种和*Uncaria tomentosa*的类化合物 (贝贝林,米特拉菲林) 抑制氧化并调节炎症体.
- 来自*Tanacetum parthenium*和*Curcuma longa*的特尔佩诺伊德 (帕特诺利德,库尔库摩尔) 降低了细胞因子水平,并抑制了COX-2和iNOS.
结论:
- 来自热带美洲植物的生物活性化合物具有作为免疫-炎症反应调节者的巨大潜力.
- 这些天然产品为开发针对严重细胞因子风暴效应的新型治疗剂提供了有希望的基础.
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