在一个适合口服输送的纳米形式中开发了甘油抗生素万科米,一种糖抗生素
Ali A Amer1, Lewis Bingle2, Cheng Shu Chaw1
1School of Pharmacy and Pharmaceutical Sciences, Faculty of Health Sciences and Wellbeing, University of Sunderland, Sunderland SR1 3SD, UK.
Molecules (Basel, Switzerland)
|April 26, 2025
概括
这项研究开发了用于口腔膜的氏素HCl (VCM) 阴osomal纳米配方. 这些阴带性口腔膜在牙科和全身应用中为治疗细菌感染提供了一个有希望的,非侵入性的替代方案.
科学领域:
- 制药纳米技术 制药纳米技术
- 药物输送系统 药物输送系统
- 抗菌研究 抗菌研究
背景情况:
- 抗生素耐药性对全球健康构成重大威胁,需要新的药物输送策略.
- 米素HCl (VCM),一个静脉注射的抗生素,用于格拉姆阳性感染,由于其化学特性,口服生物可用性受到限制.
- 开发替代性,对患者友好的VCM配方对于扩大其治疗应用至关重要.
研究的目的:
- 为增强口服输送,将万科米辛化 (VCM) 制成一个尼奥索姆纳米形式.
- 封装载有VCM的体体到快速分解的口腔膜中,用于治疗口腔感染.
- 评估开发的配方的物理化学特性和体外抗菌疗效.
主要方法:
- 用微流体技术与各种表面活性剂 (Span 40,Span 60,Kolliphor RH40,Kolliphor ELP) 和胆固醇制备封装VCM的体.
- 涅体的特征是尺寸 (动态光散射),封装效率 (高性能液体染色学) 和抗菌活性 (对*Bacillus subtilis*的agar扩散方法).
- 将VCM阴osomal配方纳入聚乙烯醇 (PVA) 口膜中,并评估膜的特性 (重量,灵活性,分解时间).
主要成果:
- 最佳配方的VCM载荷体呈现出小直径,可接受的多分散性和高药物封装效率.
- 尼奥索姆配方显示VCM的持续释放和显著的体外抗菌活性对阳性细菌.
- 含有VCM体的快速分解的口腔膜显示出均的重量,优异的灵活性和快速分解 (105±12秒).
结论:
- 微流体技术成功地产生了具有狭窄尺寸分布的VCM载荷体.
- 将VCM体纳入快速分解的口腔膜提供了一个非侵入性的,对患者友好的输送系统.
- 这种方法对治疗口腔细菌感染和潜在的全身应用有希望.
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