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评估离子电池热失控排放的吸入风险和毒理影响

Maureen Meister¹, Shaligram Sharma¹, Xiaojia He¹

¹Chemical Insights Research Institute of UL Research Institutes, Marietta, GA 30367, United States.

Environment international

|April 26, 2025

概括

离子电池的热失控会释放有害颗粒. 铜 (NMC) 电池排放导致肺细胞的细胞损伤,氧化应激和DNA修复中断.

科学领域:

环境健康环境健康
材料科学材料科学材料科学
毒理学毒理学毒理学

背景情况:

对离子电池 (LIB) 的需求增加增加了热逃跑 (TR) 事件的频率.
来自LIB TR颗粒物排放的吸入风险在很大程度上是未知的.
了解这些风险对于公共健康和安全至关重要.

研究的目的:

评估LIB TR颗粒物排放对初级小气道上皮细胞 (SAEC) 的影响.
为了比较不同LIB阴极化学的TR排放的影响 (NMC与LFP).
研究细胞反应,包括生命力,氧化应激和DNA损伤.

主要方法:

在不同电荷状态下,TR在LIB中被诱导.
颗粒物排放被收集,特征,并为吸入剂量计建模.
SAEC暴露于TR提取物,并分析了细胞反应.

主要成果:

TR的排放含有含有重金属的超细颗粒.
来自,, (NMC) 的TR提取物诱导了细胞衰老和显著的活性氧物种 (ROS) 生产.
NMC 提取物破坏了DNA 修复和细胞循环调节器,导致了上皮细胞间酶转换 (EMT).

结论:

LIB TR颗粒物排放带来了严重的呼吸系统健康风险.
电池化学,特别是NMC,影响了TR排放的毒性.
氧化应激和EMT是NMC诱导的肺细胞损伤的关键机制.

关键词:

造成的DNA损伤是DNA损伤.离子电池是一种离子电池.氧化应激是一种氧化应激.颗粒物排放量颗粒物排放量热 runaway 失控的热 runaway 失控的

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