神经肌肉电刺激降低了多发性硬化症患者的脊柱刺激性,这些患者有性症状
Martina Scalia1, Riccardo Borzuola1, Martina Parrella1
1Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy.
Multiple sclerosis and related disorders
|April 26, 2025
概括
神经肌肉电刺激 (NMES) 降低了多发性硬化症 (MS) 患者的脊柱刺激性. 这一发现为控制神经疾病中的性提供了新的治疗途径.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 临床电生理学 临床电生理学
背景情况:
- 神经肌肉电刺激 (NMES) 正在探索神经疾病,如脊髓损伤和中风,以管理性.
- 以前的研究表明,NMES可能会降低脊柱刺激能力,但神经生理机制仍未得到研究,特别是在多发性硬化症 (MS) 中.
研究的目的:
- 调查NMES对MS患者脊柱激发能力的急性影响,有和没有性.
- 为了比较H反射响应在同位数自愿收缩 (ISO),被动NMES (pNMES) 和结合NMES与自愿收缩 (NMES+) 的情况下.
主要方法:
- 15名患有性多发性硬化 (MS+) 的多发性硬化患者和15名没有 (MS-) 的多发性硬化患者参与了这项研究.
- 测量Soleus (SOL) H-反射幅度之前和之后,ISO,PNMES和NMES+条件应用于足部 flexor 肌肉.
- 参与者在20%的最大自愿异位收缩 (MVIC) 时进行了6秒的收缩.
主要成果:
- 在MS+患者中,pNMES和NMES+后的H反射幅度显著下降 (p < 0.01).
- 在MS+患者中,H-反射幅度在ISO后保持不变 (p = 0.829).
- 在MS患者中,H-反射幅度在所有疾病中没有显著变化 (p > 0.05).
结论:
- 无论是被动的还是与自愿收缩相结合的NMES应用,都会降低性MS患者的脊柱刺激能力.
- 这种降低可能是由诸如前突触抑制和GABAergic活性等机制介导的.
- 这些发现提供了神经生理学的见解,并建议NMES的潜在临床应用,用于管理MS相关的性.
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