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环境中的酸会增加Streptococcus Suis的抗生素耐药性

Wenjin Ma¹, Ziyan Kou¹, Mengya Fang¹

¹National Laboratory for Veterinary Drug Safety Evaluation, Huazhong Agriculture University, Wuhan 430070, China; MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Hubei 430070, China; College of Veterinary Medicine, Huazhong Agriculture University, Wuhan 430070, China.

Journal of hazardous materials

|April 26, 2025

概括

甲酸 (PAA) 消毒剂可以增加Streptococcus suis对 tiamulin (TIA) 抗生素的耐药性. 这一发现凸显了在农业中适当使用消毒剂的必要性,以防止抗生素耐药性.

科学领域:

环境微生物学环境微生物学
细菌耐药性的机制
公共卫生威胁公共卫生威胁

背景情况:

环境中的消毒剂可以促进抗生素耐药的细菌.
瑞杆菌 (Streptococcus suis) 是一种携带抗生素耐药基因的环境细菌.
消毒剂对诱导S. suis的抗生素耐药性的直接影响尚不清楚.

研究的目的:

调查消毒剂是否可以直接诱导瑞士链球菌的抗生素耐药性.
探索消毒剂对S. suis.抗生素耐药机制的影响.

主要方法:

使用S. suis标准菌株 (CVCC609) 和八种消毒剂的诱导实验.
评估抗生素耐药性,细菌形态,囊,活性氧物种,生物膜,细胞膜透性和ATP水平的变化.
分析与耐药性相关的关键差异表达基因.

主要成果:

64毫克/升的酸 (PAA) 显著增加了S. suis对 tiamulin (TIA) 的抗性,增加了8倍,具有遗传稳定性.
PAA治疗改变了细菌形态和囊,增加了活性氧物种和生物膜,并降低了细胞膜的透性.
鉴定出不同表达的基因,与观察到的抗性机制相关联.

结论:

甲酸 (PAA) 可以共同选择在瑞士链球菌 (Streptococcus suis.) 中的 tiamulin (TIA) 耐药性.
在牲畜和家禽养殖中消毒剂的应用需要标准化,以减轻抗生素耐药性.
了解这些机制对于公共卫生和控制细菌感染至关重要.

关键词:

抗生素耐药性基因是抗生素耐药性的基因.共同选择机制共同选择机制消毒剂消毒剂是一种消毒剂.突变突变是一种突变.佩拉乙酸是什么意思? 佩拉乙酸是什么意思

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