精子血微量元素与精子质量之间的关系
Yujie Li1, Xiaowen Liu1, Zewei Yu1
1Center for Reproductive Medicine, Women and Children's Hospital, Qingdao University, Qingdao, China; Branch of Shandong Provincial Clinical Research Center for Reproductive Health, Qingdao, China; College of Medicine, Qingdao University, Qingdao, China.
Ecotoxicology and environmental safety
|April 26, 2025
概括
男性生育能力下降与精液等离子体的微量元素有关. 某些金属的较高水平会对精子运动产生负面影响,这表明这些元素是男性生殖健康的关键生物标志物.
科学领域:
- 环境健康 环境健康
- 生殖生物学 生殖生物学
- 分析化学 分析化学
背景情况:
- 最近,男性生育能力有所下降,主要是由于精子质量下降.
- 虽然已知常见因素,但它们并不能解释所有男性不孕症病例.
- 环境微量元素在精液等离子体中对男性生育能力的作用尚不清楚.
研究的目的:
- 调查精液中的25种微量元素与男性生育能力参数之间的关系.
- 确定与中国男性精子质量下降相关的特定微量元素.
- 确定精子微量元素作为环境暴露和男性生殖细胞健康的潜在生物标志物.
主要方法:
- 诱导合等离子体质谱法 (ICP-MS) 用于量化精液等离子体中的25种微量元素.
- 从209名中国生育年龄的男性中采集了样本.
- 后勤回归和受限立方线分析了微量元素和精液参数之间的关联.
主要成果:
- 在患有精 (精子运动性降低) 的男性中发现了较高的Mg,Ca,Fe,Cu,Zn,Mn,Sr,Cd和Co水平.
- 低Mo度被观察到在男性与三精子 (异常的精子形态) 的teratozoospermia.
- 微量元素含量在小动物精子 (低精子数) 类似于健康对照;然而,Mg,Zn,Cd和低Co与精子运动负相关,而Mg,Ca,Fe,Zn,As,Cd与精子DNA碎片化正相关.
结论:
- 精液等离子体的微量元素,特别是金属,是显著的生物标志物,反映了男性生殖细胞的环境暴露.
- 增加的精子微量元素主要与精子运动性降低有关,而不是精子度或形态.
- 需要进一步的研究来阐明连接精子微量元素与男性生育能力下降的生物学机制.
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