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相关概念视频

Sperm Structure and Semen Composition01:22

Sperm Structure and Semen Composition

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During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...
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Spermatogenesis01:41

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Infertility in Males01:23

Infertility in Males

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Sperm Transport01:15

Sperm Transport

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The journey of sperm from its origin to the point of ejaculation begins within the seminiferous tubules of the testis. Here, Sertoli cells produce fluid that propels non-motile sperm through a series of conduits, starting with the straight tubules leading to the rete testis. This interconnected network of tubules acts as the initial pathway for sperm, guiding them into the efferent ductules and then into the epididymis for maturation.
The maturation phase occurs in the epididymis, where sperm...
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Testes: Histology01:27

Testes: Histology

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A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
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Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

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The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
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Sperm Collection of Differential Quality Using Density Gradient Centrifugation
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精子血微量元素与精子质量之间的关系

Yujie Li1, Xiaowen Liu1, Zewei Yu1

  • 1Center for Reproductive Medicine, Women and Children's Hospital, Qingdao University, Qingdao, China; Branch of Shandong Provincial Clinical Research Center for Reproductive Health, Qingdao, China; College of Medicine, Qingdao University, Qingdao, China.

Ecotoxicology and environmental safety
|April 26, 2025
PubMed
概括

男性生育能力下降与精液等离子体的微量元素有关. 某些金属的较高水平会对精子运动产生负面影响,这表明这些元素是男性生殖健康的关键生物标志物.

关键词:
减少男性生育能力.环境污染物环境污染物金属元素中的金属元素.精液质量 精液质量精子的微量元素 精子的微量元素

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科学领域:

  • 环境健康 环境健康
  • 生殖生物学 生殖生物学
  • 分析化学 分析化学

背景情况:

  • 最近,男性生育能力有所下降,主要是由于精子质量下降.
  • 虽然已知常见因素,但它们并不能解释所有男性不孕症病例.
  • 环境微量元素在精液等离子体中对男性生育能力的作用尚不清楚.

研究的目的:

  • 调查精液中的25种微量元素与男性生育能力参数之间的关系.
  • 确定与中国男性精子质量下降相关的特定微量元素.
  • 确定精子微量元素作为环境暴露和男性生殖细胞健康的潜在生物标志物.

主要方法:

  • 诱导合等离子体质谱法 (ICP-MS) 用于量化精液等离子体中的25种微量元素.
  • 从209名中国生育年龄的男性中采集了样本.
  • 后勤回归和受限立方线分析了微量元素和精液参数之间的关联.

主要成果:

  • 在患有精 (精子运动性降低) 的男性中发现了较高的Mg,Ca,Fe,Cu,Zn,Mn,Sr,Cd和Co水平.
  • 低Mo度被观察到在男性与三精子 (异常的精子形态) 的teratozoospermia.
  • 微量元素含量在小动物精子 (低精子数) 类似于健康对照;然而,Mg,Zn,Cd和低Co与精子运动负相关,而Mg,Ca,Fe,Zn,As,Cd与精子DNA碎片化正相关.

结论:

  • 精液等离子体的微量元素,特别是金属,是显著的生物标志物,反映了男性生殖细胞的环境暴露.
  • 增加的精子微量元素主要与精子运动性降低有关,而不是精子度或形态.
  • 需要进一步的研究来阐明连接精子微量元素与男性生育能力下降的生物学机制.