针对晚期喉状细胞癌的个性化治疗策略和预后:来自机器学习模型的见解
Sakhr Alshwayyat1, Alia Alawneh2, Haya Kamal3
1King Hussein Cancer Center, Amman, Jordan; Princess Basma Teaching Hospital, Irbid, Jordan; Applied Science Research Center, Applied Science Private University, Amman, Jordan.
American journal of otolaryngology
|April 26, 2025
概括
对于晚期喉平细胞癌 (LSCC),结合手术和放射治疗提供了最好的生存结果. 机器学习模型强调年龄,性别和阶段作为个性化治疗策略的关键预后因素.
科学领域:
- 在瘤学瘤学.
- 医疗信息学 医疗信息学
- 生物统计学 生物统计学
背景情况:
- 喉状细胞癌 (LSCC) 死亡率正在增加,尽管有各种治疗方法.
- 开发有效的预后模型对于管理先进的LSCC至关重要.
研究的目的:
- 评估不同治疗选择对晚期LSCC生存的影响.
- 为个性化治疗决策建立基于机器学习的预后模型.
主要方法:
- 利用SEER数据库进行生存分析和机器学习 (ML) 模型开发.
- 采用了考克斯回归,五个ML算法,ROC曲线分析和卡普兰-梅尔生存分析.
- 确定了LSCC患者的预后变量和预测的5年生存期.
主要成果:
- 包括7350名LSCC患者 (结节,上结节,下结节).
- 机器学习模型将年龄,性别和阶段确定为关键的生存因素.
- 手术和放射治疗 (RT) 在所有解剖学部位表现出最好的生存结果.
结论:
- 多模式治疗,特别是手术和放射治疗,对于先进的LSCC管理至关重要.
- 考虑年龄,性别和瘤阶段的个性化治疗计划至关重要.
- 化疗对整体存活率没有显著影响,表明需要修订治疗方案.
相关概念视频
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Cancer Survival Analysis
334
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
334
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K


