咖啡消费和多发性硬化症风险:系统性审查和元分析
Mehrad Amirnia1, Khazar Raeisnia1, Hamidreza Ashayeri2
1Research Center for Evidence-Based Medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran; Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Autoimmunity reviews
|April 26, 2025
概括
咖啡消费可能会降低患多发性硬化症 (MS) 的风险. 这一系统性审查发现,喝咖啡与MS诊断的可能性较低之间存在显著的关联,突出了其潜在的保护作用.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 多发性硬化症 (MS) 是一种免疫媒介的神经系统疾病,具有复杂的病因因素.
- 在咖啡中发现的咖啡因具有潜在的神经保护和抗炎性质.
- 现有的关于咖啡消费和MS风险的临床证据是相互矛盾的,需要进行全面的审查.
研究的目的:
- 系统地审查和综合现有关于咖啡消费与患多发性硬化症 (MS) 风险之间的联系的文献.
- 解决当前临床证据中关于咖啡对MS风险的影响的不一致性.
主要方法:
- 在主要数据库 (PubMed,Scopus,Web of Science,Embase) 进行了系统的文献搜索,直到2024年1月,遵守PRISMA 2020指南.
- 包括评估咖啡摄入量和MS风险的观察性研究;不包括评论,病例报告,非英语论文和非人类研究.
- 使用JBI检查清单评估偏差风险,并使用CMA软件使用赔率比率 (OR) 进行元分析.
主要成果:
- 十项涉及19430名参与者的观察性研究符合纳入标准,显示了整体高质量.
- 分析表明,咖啡消费者患MS的风险降低 (OR:0.66;95%CI:0.49-0.90).
- 在对潜在混因素进行调整后,这种保护性关联仍然存在 (调整后OR:0.42;95%CI:0.20-0.90).
结论:
- 咖啡消费似乎与患多发性硬化症 (MS) 的风险降低有关.
- 需要进一步的高质量,精心设计的前性研究来证实这一关联.
- 这项研究已注册为PROSPERO (CRD42023484298).
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