在GO/NOGO任务期间,频率特定的网络连接障碍与严重抑郁症患者的自杀企图有关
Zhongpeng Dai1, Yi Xia2, Hongliang Zhou2
1State Key Laboratory of Brain and Cognitive Sciences, Laboratory of Neuropsychology & Human Neuroscience, The University of Hong Kong, Hong Kong; School of Biological Sciences & Medical Engineering, Child Development and Learning Science, Key Laboratory of Child Development and Learning Science, Ministry of Education, Research Center for Learning Science, Southeast University, Nanjing 210096, China.
Journal of affective disorders
|April 26, 2025
概括
试图自杀的严重抑郁症患者表现出明显的脑活动模式. 在认知任务期间大脑连接和振荡的改变可能表明这些人的认知控制受损.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 大型抑郁症 (MDD) 是自杀的重要危险因素.
- 了解MDD患者自杀企图 (SAs) 的神经生物学至关重要.
研究的目的:
- 在MDD患者中,在执行和抑制任务期间调查频率特定的功能连接模式,有或没有SA史.
- 为了确定与抑郁症中SA相关的神经生物学标志物.
主要方法:
- 143名受试者 (43名健康对照,87名MDD患者[43名SA,44名无SA]) 在GO/NOGO任务期间接受了磁脑扫描 (MEG).
- 分析了时间频率特征和频率特定的大脑网络连接.
- 收集行为数据并进行神经认知评估.
主要成果:
- 在行为和神经认知测试中,SA组的表现更差.
- 在SA组中,在GO (降低) 和NOGO (增加) 条件下观察到改变的α/β振荡.
- 在GO试验中识别出异常的前额-边缘 (α频段) 和前额-头 (β频段) 连接,并在SA组中NOGO试验中识别出前额-头 (α频段) 和前额-头 (β频段) 连接.
结论:
- 改变的α/β振荡和连接模式与抑郁症中的SA有关.
- 患有SA的抑郁患者可能有认知控制功能受损.
- 频率特定的神经成像特征可以预测SA,并与自杀风险和认知缺陷相关联.
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