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高度疫苗接种的大城市城市百日咳流行病学模式:重庆的政策影响和控制策略,中国,2005-2024年

Rui Shen¹, Jiawei Xu², Yugang Li¹

¹Public Health Emergency Management Innovation Center, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Key Laboratory of Pathogen Infection Prevention and Control, Peking Union Medical College, Ministry of Education, Beijing, China; State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

|April 26, 2025

概括

尽管疫苗接种率很高,但咳在城市中正在复苏. 针对学龄儿童的疫苗接种策略可以显著减少百日咳的传播,并保护婴儿.

科学领域:

流行病学流行病学
公共卫生公共卫生
传染病建模传染病建模

背景情况:

百日咳 (百日咳) 复发在城市地区的高疫苗覆盖率挑战控制.
了解传播动态对于大城市的有效公共卫生干预至关重要.

研究的目的:

为了调查中国重庆的百日咳流行病学模式.
评估不同疫苗接种策略在人口密的城市环境中对百日咳控制的影响.

主要方法:

利用了2005-2024年以人口为基础的监测数据.
采用分层贝叶斯空间建模和年龄结构传输分析.
模拟了2025-2027年的四个疫苗接种策略,以评估其影响.

主要成果:

百日咳的发病率显著增加,婴儿和学龄儿童的风险更高.
分子诊断揭示了大量的隐藏传播,特别是在城市地区.
建模表明,延长学龄增强剂 (5-7岁) 可以将发病率降低47.93%.

结论:

加强分子监测对于检测城市环境中隐藏的百日咳传播至关重要.
针对学龄儿童的有针对性的疫苗接种可以破坏传播链并保护婴儿.

关键词:

分子诊断学分子诊断学百日咳百日咳是一种疾病.学校年龄传染的发生在学校.城市流行病学城市流行病学接种疫苗的政策

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