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设计,合成和评估光PI3K抑制剂作为双重功能药物,用于癌症治疗

Ge Shi1, Hua Tian2, Shiji Chu2

  • 1Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; CAMS Key Laboratory of Small Molecule Immuno-Oncology Drug Discovery, Chinese Academy of Medical Sciences, Beijing 100050, China.

Bioorganic & medicinal chemistry letters
|April 26, 2025
PubMed
概括

研究人员开发了一种新型的光抑制剂,向氏化物3-酶 (PI3K). 这种双重作用分子抑制PI3K,并允许实时跟踪癌细胞和瘤中的药物分布.

关键词:
癌症治疗术 癌症治疗术具有双重功能的功能.光抑制剂的光抑制剂在PI3K中,PI3K是指PI3K.

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