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相关概念视频

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

16
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
12.8K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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相关实验视频

Updated: May 10, 2025

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
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Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

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与PTSD相关的细胞类型特定和炎症性DNA甲基化模式.

Alicia K Smith1, Seyma Katrinli2, Adam X Maihofer3

  • 1Emory University, Department of Gynecology and Obstetrics, Atlanta, GA, USA; Emory University, Department of Human Genetics, Atlanta, GA, USA; Emory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.

Brain, behavior, and immunity
|April 26, 2025
PubMed
概括

这项研究揭示了创伤后应激障碍 (PTSD) 患者的免疫细胞中明显的DNA甲基化模式. 免疫细胞中的这些表观遗传变化突出显示了炎症.

关键词:
乙细胞是B细胞的一个组成部分.在CRP中使用CRP.通过DNA甲基化.欧洲经济联盟 (EWAS) 的成员.免疫系统的免疫系统.炎症 炎症是一种炎症.创伤后应激障碍 (PTSD) 是一种创伤是一种创伤.

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Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
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Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
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Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

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相关实验视频

Last Updated: May 10, 2025

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
11:31

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

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Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
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Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
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Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

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科学领域:

  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 免疫学 免疫学 免疫学
  • 精神病学是一个精神病学.

背景情况:

  • 像DNA甲基化 (DNAm) 这样的表观遗传修饰可以被创伤性压力改变.
  • DNAm模式可以区分患有和没有创伤后应激障碍 (PTSD) 的个体.
  • 这项研究研究了细胞类型特定的DNAm模式和PTSD中的炎症.

研究的目的:

  • 检查与PTSD相关的特定免疫细胞类型中的DNA甲基化模式.
  • 为了确定PTSD病例和对照之间的免疫细胞中的表观遗传差异.

主要方法:

  • 从11个队伍中3,277名参与者的血液样本中分析DNAm.
  • 使用了MethylationEPIC BeadChip和一个标准化的质量控制管道.
  • 进行了细胞组成的归算,并确定了与PTSD相关的细胞类型特定的DNAm模式,控制共变量,然后进行元分析.

主要成果:

  • 与对照组相比,PTSD病例的B细胞和NK细胞比例较低,中性粒细胞比例较高.
  • 在六种免疫细胞类型中确定了96种与PTSD相关的CPG,主要在B细胞中 (PTSD中甲基化低的95%).
  • 在最近的一项PTSD全基因组协会研究 (GWAS) 中,B细胞中与PTSD相关的CPG得到了丰富.

结论:

  • 在个体免疫细胞类型中发现了与PTSD相关的新型CPG.
  • 研究结果支持免疫失调和炎症在PTSD病理生理学的参与.