在老年患者中预测2019年冠状病毒病的预测因素:探索身体组成和肌肉力量
José Reginaldo Alves de Queiroz Júnior1, Jarson P Costa-Pereira2, Rodrigo Albert Baracho Rüegg3
1Graduate Program in Medicine, Medical Science Center Federal University of Pernambuco, Recife, PE, Brazil.
Clinical nutrition ESPEN
|April 26, 2025
概括
老年人体脂肪百分比较高与患上2019年新冠肺炎疾病 (COVID-19) 的风险增加有关. 这一发现凸显了管理身体成分的重要性,以潜在地减少该人口中的COVID-19发病率.
科学领域:
- 老年学是一门学科.
- 传染性疾病 传染性疾病
- 营养科学 营养科学
背景情况:
- 在2019年冠状病毒疾病 (COVID-19) 中的炎症反应会影响营养状况.
- 预先存在的身体组成和肌肉功能变化被认为是COVID-19风险因素.
- 需要进行研究,以了解身体成分如何影响老年人COVID-19风险.
研究的目的:
- 调查身体组成异常与肌肉功能之间的关联.
- 确定这些因素与老年患者COVID-19发病率之间的关系.
主要方法:
- 一项涉及老年患者的队列研究的二次分析.
- 通过生物电阻分析 (BIA) 评估身体组成,测量脂肪质量,总体水量 (TBW) 和附性瘦软组织 (ALST/ALSTI).
- 使用手握强度 (HGS) 测试评估肌肉功能;通过采访收集的COVID-19状态 12-24个月出院后.
主要成果:
- 分析包括120名受试者 (平均年龄69岁).
- 脂肪质量百分比升高独立预测了COVID-19感染 (调整HR 1.11).
- 较高的TBW%显示出降低COVID-19风险的趋势 (调整后HR为0.94);ALST,ALSTI和HGS与感染风险没有显著关联.
结论:
- 老年患者的多余体脂肪与潜在的减轻COVID-19感染风险有关.
- 管理身体成分,特别是减少多余的脂肪,可能是降低老年人COVID-19发病率的策略.
相关概念视频
Factors Affecting Illness
4.1K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.1K
Factors Affecting the Risk of Infection
10.6K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
10.6K
The Effect of Aging on Tissues
2.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.0K
Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
Muscle Recovery and Fatigue
1.9K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
1.9K
Factors Affecting Protein-Drug Binding: Patient-Related Factors
32
Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
32


