卵巢过度刺激综合征 - 过去的并发症
1Department of Obstetrics and Gynaecology, Koç University School of Medicine, Istanbul, Turkey; ART Fertility Clinics, Dubai, United Arab Emirates.
Reproductive biomedicine online
|April 26, 2025
概括
由于新的方法,卵巢过度刺激综合征 (OHSS) 现在很少见. 用激素释放性激素的激素激应剂 (GnRHa) 取代人类胆管性激素 (HCG) 触发剂可显著降低OHSS风险.
科学领域:
- 生殖内分泌学和不孕症治疗.
背景情况:
- 卵巢过度刺激综合征 (OHSS) 是由血管内皮生长因子 (VEGF) 驱动的血管透性增加引起的.
- 高水平的黄素化颗粒状细胞受到人类胆性腺激素 (HCG) 的刺激,是OHSS的主要原因,导致严重的并发症.
研究的目的:
- 审查OHSS预防策略的演变.
- 突出现代方法在减轻OHSS风险方面的有效性.
主要方法:
- 用性腺激素释放激素激动剂 (GnRHa) 取代HCG触发剂来诱导排卵.
- 在分割周期中实施玻璃化和结所有策略.
- 使用GnRH抗剂和多巴胺激动剂以进一步降低OHSS风险.
主要成果:
- 激活GnRHa可通过诱导快速解来显著降低OHSS风险.
- 在GnRHa触发后的所有结方法可以防止严重的,晚发的OHSS.
- 综合策略使OHSS成为极其罕见的并发症.
结论:
- 现代辅助生殖技术已经在很大程度上克服了与OHSS相关的风险.
- 患者可以接受卵巢刺激,减少对OHSS的恐惧,从而实现成功的生育治疗.
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