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固体器官移植患者的IPMN自然史和管理:有什么不同吗?
Melissa E Chen1, Chirag S Desai1
1Division of Abdominal Transplantation, Department of Surgery, University of North Carolina School of Medicine, United States.
概括
在移植患者中,穿管内皮质粘膜瘤 (IPMNs) 不需要特殊的管理. 这次审查没有发现IPMNs影响移植候选人,监测或癌症转化率的证据.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 移植手术 移植手术
- 在瘤学瘤学.
背景情况:
- 导管内 papillary 粘膜瘤 (IPMN) 是前恶性胰腺病变,现有管理指南.
- 移植患者在管理癌前疾病方面提出了独特的考虑.
- 对移植受体的IPMN管理需要基于证据的指导.
研究的目的:
- 系统地审查和综合管理移植候选人和接受者的IPMNs的证据.
- 确定IPMN是否影响移植资格,清单,监测或移植后结果.
- 为移植群体的IPMN管理提供基于证据的建议.
主要方法:
- 2004年1月1日至2024年7月31日期间发表的研究的系统审查.
- 在MEDLINE,Embase和Scopus数据库中搜索相关文献.
- 使用Covidence软件进行文章选和数据合成.
主要成果:
- 分析了17项涉及7023名移植患者的研究,其中339名 (4.82%) 患有IPMNs.
- 没有发现证据阻止IPMNs从移植候选人或延迟上市.
- 在移植患者中,IPMN监测和免疫抑制策略不需要修改.
结论:
- IPMNs的自然史和管理在移植和非移植患者中是相似的.
- 目前针对IPMN的监测指南适用于移植种群.
- 对于患有IPMN的移植受体,不需要对免疫抑制进行任何特定的调整.
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