在2型糖尿病丰富的队列中,认知功能的代谢特征
Jada Powell1, Christina E Hugenschmidt2, Fang-Chi Hsu3
1Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
中年代谢物,包括基米林和胆红素分解产物,与2型糖尿病 (T2D) 的晚期认知表现有关. 皮质醇与非洲裔美国人的认知功能有关,这表明压力会影响认知.
科学领域:
- 代谢学 代谢学 代谢学
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
背景情况:
- 2型糖尿病 (T2D) 是一个越来越令人担忧的疾病,与认知障碍的潜在联系.
- 了解代谢特征与认知衰退之间的关系对于早期干预至关重要.
研究的目的:
- 为了研究中年代谢物和8-10年后的认知表现之间的关联,在一个由T2D患者丰富的队列中.
- 探索这些协会中潜在的种族差异.
主要方法:
- 对欧洲裔美国人 (EAs) 和非洲裔美国人 (AAs) 进行了新陈代谢分析.
- 用全面的电池测量执行功能,记忆,注意力,语言和全球认知来评估认知表现.
- 用祖先特定的线性回归和错误发现率 (FDR) 校正的p值进行分析,并进行跨祖先复制和元分析.
主要成果:
- 在EA (118种代谢物) 和AA (19种代谢物) 之间观察到代谢物与认知表现相关的显著差异.
- 斯芬哥米林与认知表现有积极的关联,与之前的研究一致.
- 发现了与与胆红素氧化分解相关的代谢物的新兴关联,影响了多个认知领域.
- 皮质醇特别与AAs的认知功能有关,这表明压力和认知风险之间存在联系.
- 在复制和元分析后,四种代谢物在两种祖先中泛化.
结论:
- 中年人的新陈代谢概况与以后的生活中的认知表现有关,具有显著的种族差异.
- 与胆红素分解和皮质醇相关的代谢物需要进一步调查它们在T2D相关认知障碍中的作用.
- 识别关键代谢物可能有助于开发认知衰退的风险分层模型.
更多相关视频
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
04:10Author Spotlight: Preservation of Bioenergetic Parameters in Peripheral Blood Mononuclear Cells After Cryopreservation
Published on: October 20, 2023
相关概念视频
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Diabetes Mellitus: Type 2 and Gestational
Psychoneuroimmunology: Diabetes and Cancer
Diabetes: Symptoms, Diagnosis, and Complications
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
