在格拉姆阳性细菌中出现可转移的达普素耐药性
Tessa Marciniak1, Lukas Kirchner2, Silver A Wolf3
1Institute of Molecular Infection Biology, University of Wurzburg, Wurzburg, Germany.
npj antimicrobials and resistance
|April 26, 2025
概括
科学家们在细菌中发现了一种新的可转移的达普米抗性基因 (drc). 这一发现凸显了移动耐药性从环境细菌传播到MRSA等危险病原体的潜力.
科学领域:
- 微生物学 微生物学
- 遗传学 是一个遗传学.
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 达普托米辛是一种至关重要的最后手段抗生素,用于治疗由多抗药性格拉姆阳性细菌引起的感染.
- 虽然已知染色体突变会导致达普素耐药性,但以前还没有发现可传播的耐药性特征.
研究的目的:
- 报告发现一种获得的达普素耐药性决定因素.
- 调查这种新型耐药机制的遗传基础和传播潜力.
主要方法:
- 在与畜牧业相关的Mammaliicoccus sciuri隔离物中检测和描述达普素耐药性决定因子 (drc).
- 对drc操作子 (drcAB) 和其调节系统 (drcRS) 的遗传分析.
- 在各种细菌背景中对drc locus的功能分析,包括耐甲基金黄色葡萄球菌 (MRSA).
主要成果:
- 在Mammalicoccus sciuri菌株中发现了一种新型的,获得的达普素耐药性决定剂,称为drc.
- 该drc决定因素包括一个由两组分系统 (drcRS) 调节的两基因操作子 (drcAB),介导着达普素的失活.
- 移动DRC位点在包括MRSA在内的多种细菌物种中具有功能,并在环境和共生性格拉姆阳性细菌中循环.
结论:
- 移动DRC位点的发现代表了第一个已识别的获得的达普素耐药性特征.
- 在MRSA中DRC系统的功能及其在环境细菌中的循环构成了向临床病原体传播的重大风险.
- 低毒性微生物可以作为抗生素耐药性基因的重要储存库,需要加强监测.
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