相关实验视频

Updated: May 10, 2025

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

Published on: April 13, 2018

肺部疾病中TAM机制的最新进展

Jiaqi Ban¹, Jiayi Qian¹, Chi Zhang²

¹School of Public Health, The key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, No.6 Ankang Road, Guian New Area, Guiyang, 561113, Guizhou, China.

Journal of translational medicine

|April 26, 2025

概括

TAM受体 (TYRO3,MERTK,AXL) 对于肺部平衡至关重要,但可以导致炎症,纤维化,癌症和COVID-19肺部损伤. 了解它们的机制为肺部疾病提供了新的治疗点.

科学领域:

细胞生物学细胞生物学
免疫学免疫学免疫学
肺部病理学肺部病理学

背景情况:

TAM受体 (TYRO3,MERTK,AXL) 对于肺组织的平衡至关重要,调节细胞完整性和自我更新.
这些受体调节关键的细胞过程,包括细胞亡,增殖,分化,粘附和迁移.
TAM受体信号失调与炎症,纤维化和癌症等肺病理有关.

研究的目的:

审查TAM受体在肺部疾病发病过程中的多方面的作用.
阐明TAM受体参与肺炎,纤维化,癌症和COVID-19的机制.
探索未来的研究方向和针对肺部疾病中TAM受体的治疗策略.

主要方法:

关于TAM受体和肺部疾病的最新研究的文献综述.
通过TYRO3,MERTK和AXL调节的信号通路的分析.
综合当前关于TAM受体在恒温和疾病中的功能知识.

主要成果:

TAM受体参与抑制抗瘤免疫力,并促进对免疫检查点抑制剂的抵抗力.
它们的失调会导致病理状况,包括COVID-19引起的肺损伤.
将TAM受体与肺部疾病进展联系在一起的特定机制仍在研究中.

结论:

TAM受体在肺部健康和疾病中起着复杂的作用,充当组织平衡的关键调节者.
准TAM受体为各种肺部疾病,包括癌症和病毒感染提供了一个有希望的治疗途径.
需要进一步的研究,以完全解开TAM受体信号传递的复杂机制,在肺病理学的背景下.

关键词:

一个AXL一个AXL 在 COVID-19 疫情中,肺部疾病肺部疾病这就是MERTK的意思.这就是TYRO3的特点.

更多相关视频

Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung

Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung

Published on: May 20, 2019

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...