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Updated: May 10, 2025

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
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Published on: January 26, 2018

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H3F3A K27M突变通过调节在扩散中线质瘤中独立于H3K27me3的染色质可访问性来驱动压制性转录组

Suraj Bhattarai1, Faruck L Hakkim1, Charles A Day1,2

  • 1The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN, 55912, USA.

Epigenetics & chromatin
|April 26, 2025
PubMed
概括

扩散中线质瘤 (DMG) 中的H3.3K27M突变通过新的表观遗传变化驱动癌症,独立于多抑制复合体2 (PRC2) 抑制. 这种突变改变了染色质的可访问性和基因表达,这对瘤发育至关重要.

关键词:
这是DMG的DMG.基因组合物 基因组合物在 PRC2 中,PRC2 是 PRC2 的第一个类型.

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