与非糖尿病人群相比,糖尿病患者因任何肝脏原因的死亡率. 一项长达10年的观察性研究
Carlo B Giorda1, Roberta Picariello2, Barbara Tartaglino3
1Specialist, Free Lance Researcher and Writer in Diabetes and Endocrine Disorders, Torino, Italy.
概括
患有2型糖尿病的人患肝脏相关死亡的风险增加了三倍. 控制糖尿病,评估肝纤维化,减少饮酒对于降低这种风险至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 糖尿病和肝脏疾病之间的联系是死亡的原因越来越多.
- 2型糖尿病 (T2DM) 显著影响肝脏健康和死亡率.
研究的目的:
- 为了比较T2DM患者与非糖尿病患者的肝脏死亡风险.
- 确定与T2DM患者肝脏死亡率相关的风险因素和保护因素.
主要方法:
- 这是一项为期10年的观察性研究,涉及意大利400多万居民,其中包括100,611名新诊断的T2DM患者.
- 分析使用标准化死亡率 (SMR) 和Poisson回归来评估风险因素的死亡率.
主要成果:
- 患有T2DM的患者患有与肝脏相关的死亡风险高出三倍 (9.96 vs 3.02 / 10,000).
- 肝细胞癌和与代谢功能障碍相关的脂肪性肝病是主要的死亡原因.
- 危险因素包括男性性别,年龄较大,高FIB-4分数,血糖控制不佳 (HbA1c>9%) 和滥用酒精. GLP-1 RAs和SGLT2抑制剂显示肝脏死亡率降低,而胰岛素与死亡率增加有关.
结论:
- 对T2DM患者的肝脏并发症需要有针对性的干预措施,重点是血糖控制,纤维化评估和减少酒精摄入.
- 因克雷丁和SGLT2抑制剂的潜在益处需要进一步研究,由于潜在的逆因果关系,对胰岛素的影响进行谨慎解释.
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