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在类风湿性关节炎中纤维细胞激活成像:使用FAPI PET/CT评估疾病活性和治疗反应

Xingyu Mu¹, Fangyue Zhang², Meng Li¹

¹Department of Nuclear Medicine, Affiliated Hospital of Guilin Medical University, Guilin, China.

European radiology

|April 27, 2025

概括

使用[18F]FAPI PET/CT的纤维细胞激活蛋白 (FAP) 成像显示出评估类风湿性关节炎 (RA) 疾病活动的前景. 这项技术量化了FAP表达,与临床疾病严重程度和治疗反应相关联.

科学领域:

放射学放射学是一门学科.
核医学是一种核医学.
类风湿病学类风湿病学

背景情况:

类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,其特征是关节炎症.
精确评估RA疾病活动对于有效的管理和治疗计划至关重要.
目前用于评估RA活性的方法可能无法完全捕捉潜在的生物过程.

研究的目的:

为了评估纤维细胞激活蛋白 (FAP) 图像利用[18F]FAPI PET/CT评估RA疾病活动的实用性.
为了确定[18F]FAPI PET/CT是否可以监测RA患者的治疗反应.
探索FAP成像参数与RA疾病活性的临床测量之间的相关性.

主要方法:

这是一项前性研究,涉及42名RA患者和8名健康对照.
参与者接受了临床评估和[18F]FAPI PET/CT成像.
分析了半定量PET/CT参数 (SUVmax,LMR,FLV,TLF) 并与疾病活性评分 (DAS28-CRP) 相对应.

主要成果:

[18F]FAPI PET/CT成功识别了RA受影响的关节,与对照组相比,其标志物吸收率更高.
增加的FAP表达 (SUVmax,FLV,TLF) 与较高的RA疾病活性显著相关.
在DAS28-CRP和FLV和TLF之间发现了积极的相关性,表明FAP负担反映了疾病的严重程度.

结论:

[18F]FAPI PET/CT是评估RA疾病活性的一种有价值的非侵入性工具.
图像提供了对纤维细胞激活的定量见解,有助于疾病管理.
这种技术有可能提高治疗计划和监测RA的治疗反应.

关键词:

疾病活动评估疾病活动评估纤维细胞激活的激活类风湿性关节炎类风湿性关节炎类风湿性关节炎处理过程的监控.[18F]FAPI PET/CTCT 是一个

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