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Updated: May 23, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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设计,合成,生物活性,X射线结晶学和分子对接研究的素-1,3,5-三衍生物作为抗癌剂

Xuan-Yi Xue1, Jing-Liang He1, Meng-Wei Song1

  • 1School of Pharmacy, Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Ocean University, Lianyungang 222005, People's Republic of China.

Bioorganic chemistry
|April 27, 2025
PubMed
概括

新的素-1,3,5-三衍生物显示出强大的抗癌活性,特别是在对抗宫癌细胞. 化合物4c表现出卓越的疗效,抑制了HeLa细胞增殖和瘤生长,这表明它有可能成为一种新的癌症治疗方法.

关键词:
一,三,五-三氨酸抗癌活性 抗癌活性抑制了卡斯巴酶-3的发生.克里辛 (Chrysin) 是一种酸盐.抑制了PIK的抑制作用.

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