在叶患者的口语流利任务后半段,补偿性模块间功能连接增强
Juan Li1, Fangfang Xie2, Wen Chai3
1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008; Clinical Research Center for Epileptic Disease of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008.
叶 (TLE) 患者在语言任务中显示出大脑连接的改变. 大脑模块之间的增强通信可能会弥补语言衰退,提供潜在的治疗目标.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 神经学 神经学
背景情况:
- 语言子系统之间的动态相互作用中断可能会损害叶患者的适应能力.
- 这些动态相互作用的确切机制尚不清楚.
- 汉字口语流利 (VFC) 任务提供了一个独特的工具来研究动态语言网络交互,因为其复杂的需求.
研究的目的:
- 研究TLE患者语言网络中的动态功能连接性改变.
- 在VFC任务中比较TLE患者和神经类型对照者之间的功能连接模式.
- 探索连接性变化与口语流性表现之间的关系.
主要方法:
- 在VFC任务期间,从58名TLE患者和29名对照人群获得了功能性MRI数据.
- 从任务块的前半到后半部分分析了功能连接的变化.
- 使用滑动窗口方法来评估模块招聘和集成.
主要成果:
- 在后半部分的任务中,TLE患者在左前和前模块之间表现出增强的功能连接.
- 在TLE患者中,前模块内的内模块连接受损.
- 在TLE患者中观察到模块之间更大的整合,与更好的VFC性能相关.
结论:
- TLE患者表现出降低的内部模块和增强的内部模块动态功能连接.
- 在TLE患者中增加的模块间连接性可能代表语言功能的补偿机制.
- 这些发现表明,模块间连接是旨在缓解TLE语言衰退的干预措施的潜在目标.
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