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慢性非特异性部疼痛患者的结构性大脑变化和临床关联

Rungtawan Chaikla¹, Munlika Sremakaew¹, Suwit Saekho²

¹Department of Physical Therapy, Integrated Neuro-Musculoskeletal, Chronic Disease, and Aging Research Engagement Center (I-CARE Center), Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.

Musculoskeletal science & practice

|April 27, 2025

概括

慢性部疼痛与大脑结构变化有关,包括皮质厚度增加和关键区域灰质体积减少. 这些变化与疼痛严重程度和残疾相关.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
疼痛研究疼痛研究

背景情况:

众所周知,慢性疼痛,特别是慢性非特异性部疼痛 (CNSNP),会改变大脑结构.
CNSNP患者的特定形态大脑变化尚不清楚.

研究的目的:

在CNSNP患者中调查大脑形态变化.
探索这些形态变化与临床部疼痛特征之间的关系.

主要方法:

这是一项涉及30名CNSNP患者和30名对照者的横截面研究.
用T1加权的结构性MRI来评估皮质厚度和灰质体积.
分析包括全脑,全球和感兴趣区域 (ROI) 方法,疼痛结果如强度,持续时间,残疾和压力疼痛值 (PPT).

主要成果:

在CNSNP患者中,皮质厚度增加,灰质体积减少,这些区域包括前皮质,上边皮质和皮质.
在总厚度,总体积和特定的ROI中观察到显著的差异,包括主要体感皮质 (S1),前带皮质 (ACC) 和insula.
缩小胰岛体积与高部残疾相关,而增加PPT与更大的S1和前骨厚度和S1体积相关.

结论:

CNSNP与明显的脑形态变化有关.
这些变化包括皮质厚度增加和灰质体积减少,这些变化在关键的疼痛处理,情绪和认知方面至关重要.
在CNSNP患者中,大脑结构的改变与临床疼痛经历有关.

关键词:

大脑形态学大脑形态学皮层厚度皮层厚度灰色物质体积,灰色物质体积.磁共振成像技术磁共振成像技术部疼痛部疼痛部疼痛

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