基因组改变,分子向治疗和生存:一个真实世界的子宫内膜癌分子向治疗联盟队列研究
Angeles Alvarez Secord1, Victoria Bae-Jump2, Floor Backes3
1Duke School of Medicine, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Durham, NC, USA.
概括
在先进的子宫内膜癌中,下一代测序经常能识别出可操作的基因组变化. 与化学疗法相比,匹配的生物疗法在这个患者队列中改善了生存率.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 精准医学是一门精准的医学.
背景情况:
- 下一代测序 (NGS) 和瘤检测越来越多地用于晚期/复发的子宫内膜癌.
- 这些分子分析方法的临床影响仍在调查中.
研究的目的:
- 确定晚期/复发性子宫内膜癌中具有可操作的基因组变异的患者的比例.
- 评估分子向疗法是否能改善转移性子宫内膜癌的存活率.
主要方法:
- 一个多学科的联盟分析了来自12个中心967名患者的数据.
- 瘤检测,包括NGS,以及治疗决策是基于医生的建议.
- 数据包括患者人口统计,瘤特征,基因组变化,蛋白质表达和生存结果.
主要成果:
- 93.3%的患者接受了瘤检测,94.0%的接受NGS的患者发现了至少一种基因组变异.
- 最常见的变异是PI3K (35.8%),TP53 (34.7%) 和PTEN (26.5%) 的突变.
- 233名患者接受了匹配的生物疗法,与化疗相比,无进展和整体存活率有所改善.
结论:
- 关于基因组测试模式和向治疗使用的真实世界数据为多样化的子宫内膜癌队列建立.
- 匹配的生物疗法在晚期/复发性子宫内膜癌患者中显示出生存益处.
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