相关实验视频

Updated: May 10, 2025

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

Published on: September 28, 2022

暴露于per-和多基基物质和血液癌症:系统性审查和元分析

Michele Sassano¹, Sirui Zhang², Elizabeth Maria Kappil²

¹Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.

Cancer epidemiology

|April 27, 2025

概括

暴露在per-和多基基物质 (PFAS) 中可能与血液癌症有关. 这一系统性审查发现了PFAS和非霍奇金淋巴瘤之间的暗示性关联,与男性其他血液癌症的微弱联系.

科学领域:

环境健康环境健康
流行病学流行病学
毒理学毒理学毒理学

背景情况:

和多基基物质 (PFAS) 是广泛存在的环境污染物.
新出现的证据表明,PFAS暴露与癌症风险增加之间存在潜在联系.
由于不确的发现,PFAS和血液癌症之间的关联需要进一步调查.

研究的目的:

系统地审查和分析有关PFAS暴露与血液癌症之间关联的流行病学研究.
研究PFAS与特定类型的血液性恶性瘤 (包括白血病和淋巴瘤) 之间的关系.
提供关于PFAS和血液癌症风险的当前证据的全面摘要.

主要方法:

在PubMed和Scopus数据库的系统文献搜索 (2025年4月).
包括检查PFAS暴露和癌症的流行病学研究,不包括肝脏,脏和丸.
使用限制最大概率 (REML) 的相对风险 (RRs) 和95%置信区间 (CI) 的元分析.

主要成果:

在分析中包括了14项研究.
聚合的RR显示PFAS暴露与总血液癌症 (RR:1.04),白血病 (RR:1.04) 或淋巴瘤 (RR:1.06) 之间没有显著的关联.
在PFAS暴露和非霍奇金淋巴瘤发病率之间发现了显著的关联 (RR: 1.15). 在男性的全血性癌症和白血病中发现了弱相关性.

结论:

PFAS暴露与非霍奇金淋巴瘤的风险增加有关.
证据表明PFAS与其他血液癌症 (包括白血病和霍奇金淋巴瘤) 之间的关联是有限的.
需要进一步的研究来证实这些发现,解决流行病学研究中的潜在暴露错误分类问题.

关键词:

血液癌症是一种血液癌症.进行元分析分析.在PFAS中,我们可以使用PFAS.和多醇基物质是多和多的.系统性审查系统性审查

更多相关视频

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Published on: April 18, 2019

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

Published on: February 24, 2014

相关概念视频

Types of Toxins

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...