基线感知压力是治疗耐药抑郁症中胺/胺治疗反应的预测因素
Stefanie Cavalcanti1, Vanessa K Pazdernik2, Jennifer L Vande Voort1
1Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States of America.
Journal of affective disorders
|April 27, 2025
概括
治疗耐药性抑郁症 (TRD) 患者的高压力水平预测胺治疗的结果较差. 减少感知压力可能会提高TRD的缓解率.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 慢性压力是抑郁症的一个已知的危险因素.
- 压力也可能导致抑郁症的治疗阻力.
- 感知到的压力是心理健康结果的一个可衡量的因素.
研究的目的:
- 检查基线感知压力与治疗耐药抑郁症 (TRD) 的成年人胺治疗反应之间的关联.
- 确定感知压力水平是否影响TRD患者的缓解率和缓解所需的治疗次数.
主要方法:
- 一项历史的队列研究包括了成年TRD患者,这些患者接受了静脉注射的赛血胺或鼻腔内胺.
- 基线感知压力使用感知压力量表 (PSS) 进行测量,并将其分类为低至中等 (PSS <27) 或高 (PSS ≥27).
- 抑郁症症状 (QIDS-SR),缓解状态和治疗次数使用相关性,费舍尔的精确测试,克鲁斯卡尔-瓦利斯和费尔斯的逻辑回归来分析.
主要成果:
- 在39名TRD患者中,66.7%的人报告高感知压力 (PSS≥27).
- 高的PSS得分与缓解所需的较多的胺治疗相关 (中位数为3对1,p=0.04).
- 每增加5个点的PSS得分减少了60%的缓解几率 (OR=0.40,p=0.009),不管抑郁症的严重程度或兴奋剂的使用.
结论:
- 在接受胺的TRD患者中,高基线感知压力与较低的缓解率和增加的治疗需求有关.
- 研究结果表明,压力减轻策略可能会提高TRD的胺治疗结果.
- 需要进一步的研究来区分急性与慢性压力的影响,并探索综合治疗方法.
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