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Updated: May 15, 2025

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
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在B细胞淋巴瘤中CD19 CAR-T后的细胞因子释放综合征和神经毒性

Roni Shouval1, Christopher Strouse2, Soyoung Kim3

  • 1Adult BMT Service, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medicine, New York, New York.

Transplantation and cellular therapy
|April 27, 2025
PubMed
概括

对大型B细胞淋巴瘤的化学抗原受体T细胞 (CAR-T) 治疗显示严重细胞因子释放综合征 (CRS) 的降低,但持续的严重免疫效应细胞相关神经毒性综合征 (ICANS). 这些毒性相互关联,影响整体存活率.

关键词:
在CAR T细胞毒性方面.细胞因子释放综合征是什么大型B细胞淋巴瘤

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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