长期暴露于空气污染和食道癌症发病率:一项大规模前性队列研究
Xuwei Tang1, Chanchan Hu1, Zhifeng Lin1
1Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, China.
Environmental research
|April 27, 2025
概括
长期暴露于二氧化和等空气污染物会增加食道癌症的风险. 控制空气污染可能会降低癌症发病率,特别是在老年人和吸烟者等弱势群体中.
科学领域:
- 环境流行病学环境流行病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 关于长期空气污染和食道癌症之间的联系的流行病学数据有限.
- 这项研究调查了这种关联及其对不同食道癌亚型的影响.
研究的目的:
- 确定长期暴露于特定空气污染物和食道癌症风险之间的关系.
- 探索食道癌组织学亚型之间的潜在风险差异.
主要方法:
- 利用英国生物库的队列数据 (444,932名参与者) 与高分辨率的空气污染数据.
- 采用时间依赖的Cox比例危险模型来评估空气污染物和食道癌症发病率之间的关联.
- 根据住宅地址估计的年度污染物度 (NO2,NOx,SO2,,PM2.5,PM10).
主要成果:
- 在PM2.5/PM10和食道癌之间没有发现任何关联.
- 对NO2,NOx,SO2和的长期暴露表明食道癌症风险的线性增加.
- 增加的风险观察到每单位增加的NO2,NOx,SO2和的度. 状细胞癌和腺癌之间没有显著的异质性.
- 老年人和吸烟者/前吸烟者对特定污染物的脆弱性增加.
结论:
- 长期暴露于环境空气污染物,如NO2,NOx,SO2和,与食道癌症风险增加有关.
- 有针对性的空气污染控制策略有可能减轻食道癌症负担.
- 公共卫生干预应考虑某些人群的不同脆弱性.
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