血清25 ((OH) D水平和非酒精性脂肪性肝病的风险在非肥胖和瘦个体中
1Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Yonsei medical journal
|April 27, 2025
概括
低维生素D水平独立增加非酒精性脂肪性肝病 (NAFLD) 的风险在没有肥胖或胰岛素抵抗的人. 维持足够的维生素D可能有助于预防这些人群中NAFLD的发展.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的健康问题.
- 维生素D缺乏在NAFLD病原体中的作用,特别是在非肥胖个体中,需要进一步研究.
研究的目的:
- 为了确定低血清25-基维生素D [25(OH) D]水平是否独立地提高了NAFLD的风险.
- 为了评估没有肥胖或胰岛素抵抗的人的风险.
主要方法:
- 分析了241,208名无症状健康检查参与者的数据.
- 基于腹部超声波,肥胖状况和血清25(OH) D水平的NAFLD风险评估.
主要成果:
- 全球NAFLD患病率为25.5%,维生素D水平有显著差异.
- 较低的血清25(OH) D水平 (<10 ng/mL) 与NAFLD的更高几率有关.
- 这种关联甚至在非肥胖和瘦个体中持续存在,而不依赖于胰岛素抵抗状态.
结论:
- 维生素D缺乏是NAFLD发展的独立风险因素.
- 保持适当的25OH) D水平可能是NAFLD的预防策略,包括在非肥胖/瘦个体中.
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