早期乳腺癌治疗和心脏事件:系统性审查
Nicolas Meillan1, Sofia Rivera2, Stéphane Ederhy3
1Oncology-radiation therapy department, Victor Dupouy Hospital, Argenteuil, France; Gustave Roussy, Comprehensive Cancer Research Center, Villejuif, France; Centre for Research in Epidemiology and Population Health, U1018 Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France; Paris-Saclay University, Unité Mixte de Recherche (UMR), 1018, Villejuif, France.
Clinical breast cancer
|April 27, 2025
概括
癌症治疗,特别是辐射和某些全身疗法,可以导致早期乳腺癌患者心脏问题. 虽然新的治疗方法似乎更安全,但控制心脏风险因素仍然至关重要.
科学领域:
- 心脏瘤学 - 心脏瘤学
- 在瘤学瘤学.
- 心血管医学 心血管医学
背景情况:
- 心血管疾病是早期乳腺癌患者,特别是那些接受放射和全身治疗的患者的重要关注点.
- 了解治疗后心脏事件的频率和类型对于患者管理至关重要.
研究的目的:
- 系统地审查和估计早期乳腺癌治疗后心脏不良事件的频率.
- 确定与心脏风险增加相关的特定治疗方法和患者因素.
主要方法:
- 在遵守PRISMA指南的基础上进行系统审查.
- 在PubMed,Scopus和Web of Science数据库中进行了搜索.
- 包括81项关于心脏事件和治疗参数异质报告的研究.
主要成果:
- 报告心脏事件的差异很大 (不到5%至34%),缺血性心脏病和膜性心脏病最常见.
- 人环素和芳酶抑制剂具有长期的心脏风险;抗HER2作用是短暂的;与免疫治疗有关的心肌炎很少见 (<1%).
- 辐射方式没有显著改变心脏风险;较新的治疗方法显示心脏事件减少,受年龄和先前风险因素的影响.
结论:
- 癌症治疗的进步似乎减少了心脏事件.
- 需要有详细的毒性和放射治疗报告的前性研究.
- 建议心脏瘤学家参与管理乳腺癌幸存者的心脏风险因素.
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