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Updated: May 23, 2025

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目标控制输注普罗波:对最近的结果进行系统审查

Pavla Šafránková1, Jan Bruthans2,3

  • 1Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, nám. Sítná 3105, Kladno, CZ-272 01, Czech Republic.

Journal of medical systems
|April 27, 2025
PubMed
概括

本综述评估了用于目标控制输液 (TCI) 麻醉的propofol药理动力学-药理动力学 (PK-PD) 模型. 目前的模型显示了可变的准确性,突出了提高剂量精度和个性化麻醉管理的需要.

关键词:
在麻醉中进行数学建模.药理动力学 药理动力学普罗波福尔 (Propofol) 是一种目标控制输注注射目标控制输注

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Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
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