在现实世界中,塞马格卢提德的各种剂量形式和眼部不良事件之间的关联
Tao Zhao1,2, Liting Zheng1,2, Yiyun Feng1,2
1Baiyun Branch, Nanfang Hospital, Southern Medical University, Guangzhou, 510599, China.
BMC ophthalmology
|April 27, 2025
概括
与口服赛马格卢提德相比,皮下赛马格卢提德显示长期眼部不良事件的风险更高. 这一发现支持对使用塞马格卢提德的患者进行仔细监测和明智选择剂型.
科学领域:
- 药物监督 药物监督 药物监督
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
背景情况:
- 将皮下和口服赛马格卢提德之间的长期眼部不良事件风险进行比较.
- 评估塞马格卢提德配方之间的特定途径安全差异.
研究的目的:
- 系统地比较与 subcutaneous 和 oral semaglutide 相关的长期眼部不良事件的风险.
- 根据塞马格卢类药物给药途径,识别安全性概况的潜在差异.
主要方法:
- 使用报告几率比率 (ROR) 技术来检测药物不良反应 (ADR) 信号.
- 从FDA不良事件报告系统 (FAERS) 数据库 (2004-2024) 中分析了数据.
- 对不同类型的西马格卢提德配方进行了人口统计学和发病时间的描述性分析.
主要成果:
- 确定了1733份眼部不良事件报告,1541份与注射剂相关,192份与片剂相关.
- 在口服 (2.17%) 与口服 (5.41%) 相比,皮下塞马格卢提德的长期眼部不良事件发生率更高.
- 视网膜并发症在皮下注射时更频繁地报告,而视力模糊是口服药片的主要问题.
结论:
- 眼部不良事件风险在皮下和口服赛马格卢提德之间存在显著差异.
- 结果提供了证据,证明了在临床实践中明智选择剂型和风险监测.
- 进一步的研究可能会阐明构成依赖于配方的眼睛风险的具体机制.
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