通过一个进化镜头研究Epsilonproteobacteria的睡眠ortologs:通过植物遗传学研究睡眠神秘
Seithikurippu R Pandi-Perumal1,2,3, Konda Mani Saravanan4, Sayan Paul5
1Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, Karnataka, 570015, India. pandiperumal2023@gmail.com.
World journal of microbiology & biotechnology
|April 27, 2025
概括
这项研究在Sulfurimonas paralvinellae中确定了保存的睡眠基因,揭示了它们的进化意义. 这些基因的适应突出了环境因素在塑造睡眠机制中的作用.
科学领域:
- 进化生物学是进化的生物学.
- 基因组学就是基因组学.
- 微生物学 微生物学
背景情况:
- 与睡眠相关的基因对于跨物种的生物功能至关重要.
- 了解极端动物中这些基因的进化,可以了解适应性.
- 一种极端类的 Sulfurimonas paralvinellae 提供了一个独特的模型来研究环境压力下的基因进化.
研究的目的:
- 研究Sulfurimonas paralvinellae中与睡眠相关的基因的进化作用和保护.
- 为了识别特定的睡眠ortologs和分析它们的序列相似性.
- 探索环境适应对这些基因的功能分歧的影响.
主要方法:
- 用基因组学分析来识别保存睡眠的精神学家.
- 对已识别的ortologs进行了序列相似性分析.
- 用基因本体学 (GO) 分析来确定这些基因的功能意义.
主要成果:
- 包括DnaK (Hsp70) ,血清基甲基转移酶 (SHMT) 和通道蛋白在内的保存睡眠正义体被确定具有显著的序列相似性 (39.13%-61.45%).
- 具有较少域的蛋白质显示出更大的保护性,如腺酸激酶 (AK) 所示.
- 在双功能蛋白-氨酸/氨酸激酶和酸酶中观察到明显的适应性,与S. paralvinellae的极端友好性有关,这表明环境对功能分歧的影响. 基因实体学分析强调了催化活性,通道功能和细胞过程是重要的,强调了离子通道在睡眠-觉醒周期中的作用.
结论:
- 正义基因相互作用是复杂的,受到由生态和进化因素驱动的亚功能化和新功能化的影响.
- 这些发现增强了对睡眠相关基因进化的理解,将其与代谢和环境变化联系起来.
- 这项研究为未来的实验研究和睡眠机制的跨分类学比较提供了基础.
相关概念视频
Gene Evolution - Fast or Slow?
7.0K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
7.0K
Evolutionary Relationships through Genome Comparisons
5.6K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.6K
Bacterial Transcription
27.7K
RNA polymerase (RNAP) carries out DNA-dependent RNA synthesis in both bacteria and eukaryotes. Bacteria do not have a membrane-bound nucleus. So, transcription and translation occur simultaneously, on the same DNA template.
Transcription can be divided into three main stages, each involving distinct DNA sequences to guide the polymerase. These are:
Transcription can be divided into three main stages, each involving distinct DNA sequences to guide the polymerase. These are:
27.7K
Bacterial RNA Polymerase
27.9K
Unlike eukaryotes, bacteria use a single RNA Polymerase (RNAP) to transcribe all genes. The different subunits of bacterial RNAPhave distinct functions. The multisubunit structure of the bacterial RNAP helps the enzyme to maintain catalytic function, facilitate assembly, interact with DNA and RNA, and self-regulate its activity.
In most genes, the transcription site is a single base present upstream of the coding sequence. Though RNAP is a catalytically efficient enzyme, it does not recognize...
In most genes, the transcription site is a single base present upstream of the coding sequence. Though RNAP is a catalytically efficient enzyme, it does not recognize...
27.9K
Circadian Rhythms and Gene Regulation
4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
The Tree of Life - Bacteria, Archaea, Eukaryotes
31.7K
The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both...
31.7K


