挪威2011-2018年手术后阿片类药物使用趋势:全国性基于注册表的研究
Per-Jostein Samuelsen1, Vidar Hjellvik2, Ingvild Odsbu2
1Regional Medicines Information and Pharmacovigilance Centre (RELIS), University Hospital of North Norway, Tromsø, Norway.
Basic & clinical pharmacology & toxicology
|April 28, 2025
概括
挪威的术后阿片类药物使用量从2011年到2018年增加,长期使用量增加. 处方转向了特拉马多尔和氧,初始剂量较低,但长效配方的使用增加.
科学领域:
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 关于北欧国家手术后阿片类药物使用趋势的数据有限.
- 了解这些趋势对于公共卫生倡议和疼痛管理策略至关重要.
研究的目的:
- 调查2011年至2018年挪威手术后阿片类药物使用的趋势.
- 分析阿片类物质分布,初始剂量和配方类型的变化.
主要方法:
- 利用挪威卫生登记处的链接数据 (处方,患者,癌症,死亡原因).
- 术后阿片类药物的使用定义为在外科手术后14天内首次开药.
- 计算期间的流行率,物质分布,初始量 (MME) 和长效配方比例,不包括癌症患者和接受维持疗法的患者.
主要成果:
- 手术后阿片类药物使用的周期流行率从每1000人 (≥15年) 的27.0增加到30.0.
- 长期使用的患病率从每1000人中2.0个上升到3.3个.
- 观察到从编码因的主导地位转向编码因和特拉马多尔的更平等的分发,氧化从3%增加到12%;氧化和特拉马多尔的初始量下降,而长效配方从5%增加到12%.
结论:
- 在挪威,手术后的阿片类药物使用在2011年至2018年间呈现出日益增长的趋势.
- 显著的转变发生在特拉马多尔和氧化方面,降低了初始剂量,但增加了长效配方的使用,这表明处方模式正在演变.
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