[慢性自发性疹和疹性血管炎的形态变化谱]
V A Smolyannikova1, O Yu Olisova1, K S Teplyakova1
1The First Sechenov Moscow State Medical University (Sechenov University), Moscow, Russia.
Arkhiv patologii
|April 28, 2025
概括
皮肤活检的组织学检查可以帮助区分慢性自发性疹 (CSU) 和状血管炎 (UV). CSU显示更多的巨细胞,而紫外线显示白细胞结晶性血管炎和中性粒细胞透.
科学领域:
- 皮肤病理学 皮肤病理学
- 免疫皮肤学 免疫皮肤学
背景情况:
- 慢性自发性疹 (CSU) 影响0.5%-1%的人口.
- 组织学检查通常不需要用于CSU诊断.
- 由于临床表现重叠,CSU和状血管炎 (UV) 之间的差异诊断可能具有挑战性.
研究的目的:
- 分析和比较CSU和UV的皮肤活检中的形态变化.
- 识别有助于CSU和UV的差异诊断的组织学特征.
主要方法:
- 分析了15名疹患者的皮肤活检样本.
- 在CSU和UV组中对中性粒细胞和巨细胞计数进行比较评估.
- 组织学检查包括托卢伊丁蓝色染色.
主要成果:
- 在CSU组 (n=5) 没有发现白细胞结晶性血管炎,轻微胀,稀疏的上皮周血管透和丰富的乳腺细胞.
- 紫外线组 (n=10) 呈现不同程度的白细胞结晶性血管炎,密集的深周血管性中性透体和较少的乳腺细胞.
- 在CSU和UV之间观察到细胞透物组成和位置的明显差异.
结论:
- 组织学检查对于区分CSU和UV是有价值的.
- 关键的区分特征包括白细胞结晶性血管炎的存在,中性粒细胞透模式和巨细胞密度.
- 建议进行全面的组织学评估,包括巨细胞和中性粒细胞计数,以准确诊断.
相关概念视频
Chronic Bowel Disorders: Introduction
331
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
331
Vascular Spasm
1.0K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
1.0K
Skin Diseases and Disorders
2.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
2.8K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
Changes in Skin Color: Clinical Perspectives
1.6K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
1.6K


