解读精神分裂症的异质性:一种多模式和多变量神经成像框架,揭示大脑症状关系和潜在的亚型
1Department of Radiology, Tianjin Key Lab of Functional Imaging, Tianjin Institute of Radiology and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin 300052, China.
Schizophrenia bulletin
|April 28, 2025
概括
精神分裂症症状的多样性源于大脑的广泛变化,而不是孤立的问题. 多模式神经成像识别了不同的患者亚型,为这种复杂疾病提供了潜在的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 精神分裂症在症状和大脑异常方面表现出显著的异质性.
- 这种症状多样性的神经生物学基础尚未得到充分理解.
- 这项研究研究了精神分裂症的各种表现中结构性和功能性大脑变化的相互作用.
研究的目的:
- 探索精神分裂症症状多样性的神经生物学基础.
- 识别与特定症状尺寸相关的多式神经成像复合指标 (MRICI).
- 基于神经成像资料,发现精神分裂症的潜在生物亚型.
主要方法:
- 在8个地点招募了495名精神分裂症患者和507名健康对照.
- 利用多变量正规相关性分析,从灰色物质体积,功能连接性和白色物质微分异构性中推导出MRICI.
- 根据MRICI资料,雇佣的K-means集群识别精神分裂症亚型.
主要成果:
- 确定了15种与症状相关的MRICI,反映了多个区域的多式脑部变化.
- 证明MRICI有效地表征症状复杂性,并且在各个患者群体中一致.
- 发现了两种不同的精神分裂症亚型,具有独特的MRICI概况和症状严重程度.
结论:
- 以症状为导向的多式MRICI可以阐明精神分裂症的异质性.
- 这些MRICI显示出潜力作为精神分裂症的生物标志物.
- 了解大脑症状相互作用是表征精神分裂症亚型的关键.
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