细菌细菌衍生的表面素通过母乳缓解子女的肠道炎症损伤
Qi Zhang1, Shuang Xie1, Qiu Zhong1
1MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary medicine, Nanjing Agricultural University, Weigang 1, Nanjing 210095, China.
Nutrients
|April 28, 2025
概括
母亲消费的表面素可以增强母乳免疫力,改善后代的肠道健康和发育. 这项研究揭示了表面素.
科学领域:
- 微生物学和免疫学
- 新生儿健康与营养新生儿健康与营养
- 胃肠道生理学 胃肠道生理学
背景情况:
- 肠道疾病显著影响婴儿健康,强调了早期免疫力和母亲保护的关键作用.
- 菌素 (Bacillus subtilis) 的酸素 (Surfactin) 具有免疫调节作用,但其通过母体肠道途径对后代的影响尚不清楚.
- 这项研究调查了母亲的表面素摄入如何影响母乳的免疫成分和随后的新生儿肠道健康.
研究的目的:
- 为了确定母乳表面素补充剂对母乳免疫性质的影响.
- 评估表面素改性母乳对新生儿肠道发育和免疫的影响.
- 阐明母亲的表面素影响后代肠道健康的机制.
主要方法:
- 怀孕的小鼠从受孕到分娩后21天,在饮用水中接受了表面素.
- 进行了交叉养实验,以隔离母乳的影响.
- 分析了新生儿肠道形态,免疫细胞种群,基因表达和对沙门氏菌和LPS的反应.
主要成果:
- 由表面素补充母乳养的幼体重增加,肠长度和密室深度改善,素和抗菌素基因表达增强.
- 交叉养表明,表面素修饰的牛奶减少了与沙门氏菌 (Salmonella typhimurium) 挑战的幼的肠道损伤,炎症和氧化应激.
- 牛奶中的表面素抑制了巨细胞中LPS诱导的促炎因素,并促进了从M1转向M2巨细胞两极分化,增加了IL-4,IL-10和TGF-β等抗炎细胞因子.
结论:
- 孕产妇摄入的表面素有利于调节母乳成分,增强新生儿肠道免疫力和发育.
- 表面素的免疫调节作用可以通过母乳转移,为婴儿健康提供潜在的营养策略.
- 了解母亲的饮食干预措施可以优化母乳,以改善婴儿的胃肠道健康和防止肠道疾病.
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