编程大脑:母亲的过度营养如何影响后代的认知衰老
Pratheba Kandasamey1, Daria Peleg-Raibstein1,2
1Institute for Neuroscience, Institute of Food Nutrition and Health, Department of Health Sciences and Technology, ETH Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland.
Nutrients
|April 28, 2025
概括
在小鼠中,母亲高脂肪饮食 (HFD) 暴露会损害后代.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 营养科学 营养科学
背景情况:
- 孕产妇过度营养是影响后代长期代谢和认知健康的重要因素.
- 产前饮食可以扰乱海马功能,但其对空间记忆的具体影响尚未完全理解.
研究的目的:
- 研究母亲高脂肪饮食 (HFD) 暴露对成年后代空间记忆的影响.
- 为了确定认知缺陷是否与体重变化有关.
主要方法:
- 雌性小鼠在怀孕前9周和怀孕期间被食HFD.
- 后代在出生后90天使用干迷宫测试,这是一个空间参考记忆任务.
主要成果:
- 暴露于母体HFD的后代表现出受损的学习能力和减少的会话内改善.
- 长期空间记忆保留的缺陷被观察到,在目标象限中花费的时间更少.
- 认知障碍在测试时独立于后代的体重.
结论:
- 母亲暴露于HFD会在成年后代中诱导特定的空间记忆缺陷,可能是通过神经发育变化.
- 这些发现强调了产前营养在认知发育和长期大脑健康中的关键作用.
- 需要进行干预措施,以解决母亲过度营养对后代大脑功能的代际影响.
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