作为预测慢性肝炎D患者对布莱维尔提德病毒学反应的创新生物标志物,HBsAg异型
Stefano D'Anna1, Romina Salpini1, Elisabetta Degasperi2
1Department of Biology, University of Rome Tor Vergata, Rome, Italy.
概括
布列维尔提德治疗 (BLV) 降低了乙型肝炎病毒 (HBV) 表面蛋白 (HBsAg) 异型在患有乙型肝炎病毒 (HDV) 相关肝硬化. 较低的基线大HBs (L-HBs) 和小HBs (S-HBs) 预测BLV治疗更好的HDV-RNA不可检测性.
科学领域:
- 肝病学和病毒性肝炎的研究研究.
- 传染病和病毒学 传染病和病毒学
- 药理学和治疗学 药理学和治疗学
背景情况:
- 肝炎D病毒 (HDV) 依赖于肝炎B病毒表面蛋白 (HBsAg) 进入肝细胞.
- HBsAg包括三种异型:大 (L-HBs),中 (M-HBs) 和小 (S-HBs),其中L-HBs通过NTCP受体介导病毒进入.
研究的目的:
- 为了研究HBsAg异型体在布莱维 (BLV) 治疗期间发生的动力变化,在患有HDV相关肝硬化症的患者中.
- 为了确定基线HBsAg异型水平,预测对BLV的治疗反应.
主要方法:
- 研究了一组67名患有HDV相关的补偿性肝硬化,接受BLV (2毫克/天) 的患者队列.
- 量化L-HBs,M-HBs和S-HBs是在基线和第48周 (W48) 使用临时ELISA进行的.
- 测量HDV-RNA水平以评估病毒学反应.
主要成果:
- 在第48周,72%的患者表现出病毒学反应,其中25.4%的患者实现了不可检测的HDV-RNA.
- 在51%,63%和31%的患者中,分别观察到S-HBs,M-HBs和L-HBs水平的下降.
- 较低的基线L-HBs (<3 ng/mL) 和S-HBs (<3400 ng/mL) 水平,特别是与低基线HDV-RNA (<5 log IU/mL) 结合使用,是W48.8时实现不可检测的HDV-RNA的显著预测因素.
结论:
- 量化L-HBs和S-HBs,以及HDV-RNA,可以反映HBV/HDV联合感染中的传染性病毒的病毒载量.
- 这些HBsAg异型为有前途的预测生物标志物,用于识别可能对布莱维尔提德治疗有好反应的患者.
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