身体构成及其结果和多发性硬化症的管理:叙事审查
Ariel Kidwell-Chandler1, Justin Jackson1, Brenda Jeng1
1Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL 60612, USA.
Nutrients
|April 28, 2025
概括
通过DEXA测量的身体成分,比BMI更全面地了解多发性硬化症 (MS) 中的肥胖情况. 未来的研究应该专注于身体组成干预措施,以改善多发性硬化症的管理.
科学领域:
- 神经学 神经学
- 代谢科学 代谢科学
- 生物医学成像技术 生物医学成像技术
背景情况:
- 肥胖越来越被认为是影响多发性硬化症 (MS) 患病率,结果和管理的一个因素.
- 在MS患者中,传统的肥胖指标,如身体质量指数 (BMI),忽略了重要的身体成分细节.
- 身体组成,包括脂肪,骨和肌肉质量,是MS研究中一个相关但经常被忽视的方面.
研究的目的:
- 突出双能X射线吸收计 (DEXA) 的实用性,用于准确评估MS的身体组成.
- 综合现有关于MS体质组成的证据,使用DEXA.
- 为了确定关于多发性硬化症的身体组成的研究差距.
主要方法:
- 一个叙述性评论,遵守叙述性评论文章评估标准 (SANRA) 的标准.
- 在PubMed上使用关键词"身体组成"和"多发性硬化症"进行文献搜索.
- 基于主题和的确定研究的专题分析和综合.
主要成果:
- 出现了三个关键主题:MS患者和对照人群之间的身体成分比较 (2次元分析),身体成分与各种结果之间的关联 (14次横截面研究),以及针对MS患者身体成分的干预措施 (11次临床试验).
结论:
- 身体构成代表了一种新的和有信息的概念,用于理解和管理多发性硬化症.
- 随机对照试验侧重于身体成分作为可修改的结果,对于推进多发性硬化症治疗至关重要.
- 进一步的研究可以提高对MS中肥胖和身体成分差的理解,从而改善临床建议.
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