结核性细菌脑膜炎的儿科患者中与不良结果相关的危险因素研究
Sarika Gupta1, Akanksha D Srivastava2
1Department of Paediatrics, King George Medical University, Lucknow, Uttar Pradesh, India.
Journal of global infectious diseases
|April 28, 2025
概括
年龄较大的儿童有意识变化,水头,脑流体与血葡萄糖比较低,或没有Bacille Calmette-Guerin (BCG) 免疫接种,在结核细菌性脑膜炎 (TBM) 中面临较高的不良结果风险. 早期治疗至关重要.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 结核细菌性脑膜炎 (TBM) 对全球儿童群体构成重大威胁.
- 确定不良结果的风险因素对于有效的管理和改善患者预后至关重要.
研究的目的:
- 评估与诊断为TBM的儿童不良结果相关的风险因素.
- 为TBM管理提供临床实践和公共卫生策略的信息.
主要方法:
- 一项回顾性队列研究,涉及2019-2023年514名儿科TBM患者.
- 使用SPSS 16.0版本进行统计分析,以确定不良结果的预测因素.
主要成果:
- 19.1%的患者经历了不良结果.
- 确定的主要危险因素包括:年龄大于5岁 (OR=2.291),意识改变 (OR=2.829),脑流与血的葡萄糖比率<50% (OR=0.410),水 (OR=2.857),缺乏BCG免疫 (OR=3.638).
结论:
- 儿童TBM是一个严重的公共卫生问题,可识别的风险因素导致不良结果.
- 及时启动抗结核治疗是必不可少的,同时针对高风险个体进行有针对性的干预.
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