相关实验视频

控制营养状况评分是肝细胞癌生存的预测指标:元分析和元回归

Yi Chen¹, Hong Cao², Jia Yao³

¹Yi Chen, Department of Interventional Radiotherapy, Huzhou Central Hospital, Affiliated Central Hospital of HuZhou University, Huzhou, Zhejiang Province 313000, P.R. China.

Pakistan journal of medical sciences

|April 28, 2025

概括

控制营养状况 (CONUT) 评分有效预测肝细胞癌 (HCC) 患者的整体存活率和无病存活率. 较高的CONUT分数表明HCC的预后较差,使其成为一个有价值的预后工具.

科学领域:

在瘤学瘤学.
肝病学肝病学是一种肝病学.
营养科学营养科学
生物统计学生物统计学

背景情况:

控制营养状况 (CONUT) 评分是各种癌症的验证预后工具.
它对肝细胞癌 (HCC) 结果的预测价值,包括整体存活率 (OS) 和无病存活率 (DFS),仍然不完全理解.
建立可靠的预后标记对于优化HCC患者管理至关重要.

研究的目的:

系统地审查和元分析有关CONUT得分在HCC中的预后效益的现有证据.
评估CONUT得分与HCC患者的整体存活率 (OS) 和无病存活率 (DFS) 之间的关联.
探索影响CONUT在HCC中的预测精度的因素.

主要方法:

在PubMed,Embase,CENTRAL和Web of Science数据库中进行了全面的文献搜索.
包括在2024年3月15日之前发表的英语研究.
进行了元分析,以计算OS和DFS的危险比率 (HR) 和95%置信区间 (CI).

主要成果:

14项研究符合纳入标准.
分析显示,CONUT得分在HCC患者中显著预测了OS (HR: 1.64,95%CI: 1.302.06) 和DFS (HR: 1.32,95%CI: 1.171.50).
敏感性分析,子组分析 (按国家和治疗) 和元回归表明,较高的CONUT截止值与CONUT和OS之间更强的关联相关.

结论:

CONUT评分作为肝细胞癌的易于访问和快速预后指标.
较高的CONUT分数显然与HCC的总生存率和无病生存率下降有关.
在HCC管理中,CONUT为风险分层和临床决策提供了有价值的工具.

关键词:

肝癌是一种肝癌.营养不良的人营养不良营养营养营养营养营养幸存的生存方式

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