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父亲的暴露和怀孕结果:系统审查和元分析

Kenechi A Aliche¹, Francis U Umeoguaju², Catherine Ikewuchi¹

¹African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, Choba, Nigeria.

Environmental health insights

|April 28, 2025

概括

父亲暴露与婴儿先天性异常风险翻倍有关. 这一系统性审查强调了需要制定法规来保护生育年龄的男性免受暴露的必要性.

科学领域:

环境健康环境健康
生殖毒理学生殖毒理学
公共卫生公共卫生

背景情况:

父亲接触是一种未经研究的妊娠不良后果的危险因素.
了解这种关联对于公共卫生干预至关重要.

研究的目的:

系统地审查和元分析关于父亲暴露和不良妊娠结果的证据.
为了评估与自发流产,低出生体重,早产,怀孕年龄小,和先天异常的关联.

主要方法:

系统搜索PubMed,Scopus和谷歌学者直到2024年8月.
包括观察性研究与父亲的暴露 (≥15μg/dL).
使用随机效应模型的元分析,遵循PRISMA 2020指南.

主要成果:

在父暴露和先天异常之间发现了显著的关联 (OR=2.09,95%CI:2.09-3.35).
没有观察到自发流产,低出生体重,早产或对孕期婴儿来说小的婴儿有显著的关联.
对于大多数结果,除了自发流产和早产外,观察到的异质性很低.

结论:

父亲暴露与先天性异常风险的增加显著相关.
建议制定职业和环境法规,针对生育年龄的男性的暴露.
需要进一步的研究,以充分阐明父亲暴露对各种妊娠结果的影响.

关键词:

有先天性异常和死胎.母亲和父亲的领导力.职业暴露职业暴露职业暴露怀孕的结果.公共卫生公共卫生.

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